Table 1. Correlation between SARS-CoV 3CL^pro activity and structural properties of substituting residues.

Position	Side chain volume	Hydrophobicity	α-helix propensity	β-sheet propensity
P5	0.331 (0.154)	0.573 (0.008)*	−0.064 (0.789)	0.711 (<0.001)*
P4	−0.424 (0.063)	0.587 (0.006)*	−0.147 (0.536)	0.315 (0.176)
P3	0.338 (0.144)	0.221 (0.349)	0.170 (0.473)	0.510 (0.022)
P2	0.255 (0.277)	0.590 (0.006)*	0.379 (0.100)	0.304 (0.192)
P1	0.038 (0.873)	−0.269 (0.252)	0.126 (0.595)	0.021 (0.931)
P1'	−0.660 (0.002)*	0.233 (0.323)	−0.222 (0.347)	−0.143 (0.548)
P2'	−0.363 (0.116)	0.022 (0.926)	−0.097 (0.685)	0.048 (0.841)
P3'	0.496 (0.026)	0.094 (0.695)	−0.017 (0.944)	0.486 (0.030)

The relative activity was correlated with scales for side chain volume, hydrophobicity, and α-helix and β-sheet propensities of the substituting residues [20], [21], [22]. The correlation coefficients and p-values (in parenthesis) were reported. Significant correlations with p-value<0.01 were bolded and marked with asterisks.