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. Author manuscript; available in PMC: 2011 Oct 1.
Published in final edited form as: Alcohol Clin Exp Res. 2010 Jul 1;34(10):1723–1732. doi: 10.1111/j.1530-0277.2010.01259.x

Figure 8.

Figure 8

In vitro exposure of alveolar macrophages to alcohol for 24h impairs phagocytosis of apoptotic cells. This effect is not reversed by pre-treatment with the cell permeable Rho inhibitor, C3 transferase (1-10μg/ml) (A). RhoA activity is not increased by either in vitro (B) or in vivo (C) exposure to alcohol, suggesting that the ROCK-dependent effects of alcohol on efferocytosis are independent of RhoA. In fact, in vivo alcohol exposure is associated with significantly decreased RhoA activity. *p<0.05 when compared to control.