Table 3. Genotype risk for DHFa.
| Without covariates | With covariatesb | |||||
|---|---|---|---|---|---|---|
| DHF | SNP | Genotype | P | OR (CI 95%) | P | OR (95% CI) |
| Probablec | rs11208534 | TT | 5.5 × 10−3 | 4.7 (1.6–13.8) | 1.4 × 10−2 | 3.9 (1.3–11.8) |
| rs2780831 | GG | 5.7 × 10−2 | 2.1 (<1.0–4.6) | 1.5 × 10−1 | 1.8 (0.8–4.0) | |
| rs310196 | TT | 2.2 × 10−2 | 0.4 (0.2–0.9) | 6.8 × 10−2 | 0.5 (0.2–1.1) | |
| Haplotype 1d | 3 SNPs | 1.3 × 10−2 | 2.7 (1.2–5.8) | 4.4 × 10−2 | 2.3 (1.0–5.2) | |
| Haplotype 2 | 2 SNPs | 1.2 × 10−2 | 2.7 (1.2–6.0) | 3.7 × 10−2 | 2.3 (1.0–5.2) | |
| Possible | rs11208534 | TT | 1.4 × 10−2 | 6.4 (1.5–28.3) | 4.0 × 10−2 | 4.9 (1.1–22.5) |
| rs2780831 | GG | 7.1 × 10−3 | 3.6 (1.4–9.3) | 3.9 × 10−2 | 2.9 (1.1–7.9) | |
| rs310196 | TT | 2.2 × 10−3 | 0.2 (0.06–0.5) | 1.0 × 10−2 | 0.2 (0.1–0.7) | |
| Haplotype 1 | 3 SNPs | 1.3 × 10−3 | 6.3 (2.1–19.5) | 7.9 × 10−3 | 4.9 (1.5–16.0) | |
| Haplotype 2 | 2 SNPs | 1.6 × 10−3 | 4.6 (1.8–11.7) | 1.3 × 10−2 | 3.6 (1.3–9.6) | |
| Combined | rs11208534 | TT | 2.9 × 10−4 | 5.2 (2.1–12.7) | 2.0 × 10−3 | 4.2 (1.7–10.4) |
| rs2780831 | GG | 2.7 × 10−3 | 2.6 (1.4–4.9) | 2.3 × 10−2 | 2.1 (1.1–4.1) | |
| rs310196 | TT | 3.0 × 10−4 | 0.3 (0.2–0.6) | 4.3 × 10−3 | 0.4 (0.2–0.7) | |
| Haplotype 1 | 3 SNPs | 2.1 × 10−4 | 3.3 (1.8–6.2) | 2.5 × 10−3 | 2.7 (1.4–5.3) | |
| Haplotype 2 | 2 SNPs | 1.1 × 10−4 | 3.7 (1.9–7.1) | 2.3 × 10−3 | 2.9 (1.5–5.8) | |
CI, confidence interval; DHF, dengue hemorrhagic fever; OR, odds ratio; SNP, single-nucleotide polymorphism.
Genotype models tested were recessive/dominant and codominant. Risk was associated with the homozygotes TT and GG, respectively, for the markers rs11208534 and rs2780831. The homozygote TT was protective for rs310196. ORs compare risk for DHF (n=50) with DF (n=236) given the genotype.
Covariates modeled: age, sex, genetic ancestry, and income index.
Probable DHF (n=30) cases fit criteria for possible DHF, but also have documented evidence of capillary leak. Possible DHF (n=20) cases have a positive dengue serology, clinical syndrome consistent with dengue, spontaneous bleeding, and low platelet counts. Combined (n=50) represents probable and possible cases.
Haplotype 1 – rs11208534, rs2780831, and rs310196. Haplotype 2 – rs11208534 and rs310196.