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. Author manuscript; available in PMC: 2011 Apr 1.
Published in final edited form as: Nat Struct Mol Biol. 2010 Sep 19;17(10):1226–1232. doi: 10.1038/nsmb.1910

Figure 2. Three-dimensional electron cryomicroscopy reconstruction of VcGspD.

Figure 2

(a, c and d) Side, top and bottom views, respectively, of the dodecameric VcGspD reconstruction at 19 Å resolution. In side view, three domains are identified from bottom to top as the periplasmic domain, the outer membrane domain and extracellular cap. (b) A slice view through the channel reveals the periplasmic vestibule, a constriction, the periplasmic gate, an extracellular chamber and an extracellular gate. The extracellular chamber is ∼100 Å wide whereas the periplasmic vestibule is ∼75 Å in diameter. The periplasmic constriction narrows the vestibule to ∼55 Å.