Table I.
Associations between RGS genes genetic polymorphisms and SPT/recurrence in HNSCC
| Gene | SNP | Position | Region | Genotype | SPT/recurrence |
Best fitting model |
||||||
| Yes, n (%) | No, n (%) | HR (95% CI)a | P value | Modelb | HR (95% CI)a | P | q | |||||
| RGS2 | rs2179653 | chr1:191037685 | 5′ flanking | GG | 103 (70.07) | 208 (70.99) | 1 | |||||
| GA | 34 (23.13) | 81 (27.65) | 0.97 (0.65–1.44) | 0.877 | Rec | 2.95 (1.52–5.74) | 0.001 | 0.010 | ||||
| AA | 10 (6.80) | 4 (1.37) | 2.93 (1.50–5.73) | 0.002 | ||||||||
| RGS13 | rs3795617 | chr1:190870313 | Near 5′ | GG | 42 (28.57) | 87 (29.69) | 1 | |||||
| GA | 80 (54.42) | 119 (40.61) | 1.18 (0.81–1.72) | 0.395 | Rec | 0.52 (0.34–0.81) | 0.003 | 0.015 | ||||
| AA | 25 (17.01) | 87 (29.69) | 0.58 (0.35–0.96) | 0.035 | ||||||||
| RGS8 | rs6670735 | chr1:180909480 | Near 5′ | AA | 68 (46.26) | 111 (38.01) | 1 | |||||
| AG | 58 (39.46) | 147 (50.34) | 0.64 (0.45–0.92) | 0.015 | Dom | 0.69 (0.49–0.96) | 0.028 | 0.053 | ||||
| GG | 21 (14.29) | 34 (11.64) | 0.86 (0.52–1.42) | 0.553 | ||||||||
| RGS11 | rs739999 | chr16:259512 | Exon | AA | 113 (77.40) | 242 (82.59) | 1 | |||||
| AG | 28 (19.18) | 47 (16.04) | 1.16 (0.76–1.77) | 0.492 | Rec | 2.88 (1.06–7.78) | 0.037 | 0.053 | ||||
| GG | 5 (3.42) | 4 (1.37) | 2.99 (1.10–8.13) | 0.031 | ||||||||
| RGS5 | rs11586945 | chr1:161420559 | Intron | GG | 96 (65.31) | 206 (70.31) | 1 | |||||
| GC | 41 (27.89) | 76 (25.94) | 1.11 (0.77–1.62) | 0.568 | Rec | 2.00 (1.04–3.85) | 0.038 | 0.053 | ||||
| CC | 10 (6.80) | 11 (3.75) | 2.06 (1.06–3.99) | 0.033 | ||||||||
| RGS3 | rs3747813 | chr9:115367281 | 5′ UTR | GG | 136 (92.52) | 258 (88.05) | 1 | |||||
| GA | 11 (7.48) | 34 (11.60) | 0.54 (0.29–1.02) | 0.056 | Dom | 0.53 (0.28–0.98) | 0.043 | 0.053 | ||||
| AA | 0 | 1 (0.34) | — | |||||||||
| RGS7 | rs6689169c | chr1:239005040 | Near 3′ | AA | 120 (81.63) | 211 (72.01) | 1 | |||||
| AG | 24 (16.33) | 79 (26.96) | 0.60 (0.38–0.94) | 0.026 | Dom | 0.65 (0.42–0.99) | 0.047 | 0.053 | ||||
| GG | 3 (2.04) | 3 (1.02) | 1.65 (0.52–5.24) | 0.397 | ||||||||
UTR, untranslated region.
a
Adjusting for age, sex, smoking, ethnicity, tumor stage, primary tumor site and treatment.
b
Dom, dominant model; Rec, recessive model.
c
rs6700378 is completely linked with rs6689169 and is not shown in the table and involved in the analysis. Bold numbers represent P values that are statistically significant at P < 0.05.