Table 2.
Patient | Salvage alloBMT |
Prior BMT | Same donor as previous BMT |
Salvage graft |
CD34+/kg | CD3+ | Patient/donor ABO |
---|---|---|---|---|---|---|---|
1 | Second transplant | BU/CYa MUD BMT | Yes | MUD BM | 4.90E + 06b | NA | A + /O + |
2 | Second transplant | CY/TBI HLA identical sibling BMTc | Yes | Allo PBSC | 5.63E + 06 | 2.10E + 08 | A + /A + |
3 | Second transplant | BU/CY HLA identical sibling BMTa | Yes | Allo PBSC | 5.46E + 06 | 4.10E + 08 | O + /B + |
4 | Second transplant | BU/CY HLA identical sibling BMTd | Yes | Allo PBSC | 2.61E + 07 | 9.93E + 08 | A + /A− |
5 | Second transplant | BU/CY HLA identical sibling BMTe | Yes | Allo PBSC | 2.31E + 06 | 2.33E + 08 | A + /O + |
6 | Second transplant | BU/CY HLA identical sibling BMTd | No | Allo PBSC | 2.56E + 06 | 4.45E + 08 | B + /B + |
7 | Third transplant | Flu/CY/TBI haploBMTf; then BU/CYd MUD BMT | Yes (different from 1st BMT) | MUD PBSC | 9.35E + 06 | 4.69E + 08 | O + /O + |
8 | Second transplant | BU/CYd MUD BMT | Yes | MUD PBSC | 7.58E + 06 | 5.65E + 08 | B + /O + |
9 | Second transplant | BU/CYd MUD BMT | Yes | MUD PBSC | 3.60E + 08 | 2.37E + 07 | O−/O + |
Abbreviations: Allo = allogeneic; Flu = fludarabine; haplo = haploidentical; MUD = matched unrelated donor.
BU (16 mg/kg) plus CY (200 mg/kg) as described by Santos et al.24
Nucleated cells/kg.
CY (200 mg/kg) plus TBI 1200 cGy as described by Wingard et al.25
BU (16 mg/kg), CY (100 mg/kg) plus post transplant CY (100 mg/kg) as described by Luznik et al.26
BU (16 mg/kg) plus CY (200 mg/kg) with T-cell-depleted graft.
Fludarabine (120 mg/m2), CY (29 mg/kg), TBI 200 cGy, plus post transplant CY (100 mg/kg) as described by Luznik et al.27