Table 3.

Multiple regression results for heavy drinking days per week

									95% CI for B
Block	F	Δr2	p-value	Predictor	B	SE	t	p-value	Lower	Upper	Δr2
1	19.752a	0.271	<0.001
				Pre-treatment HDD	0.440	0.050	8.877	<0.001	0.342	0.537	0.216
				ADS total score	−0.010	0.018	−0.540	0.590	−0.044	0.025	0.001
				BAI total score	0.010	0.013	0.749	0.455	−0.016	0.037	0.002
				AD criteria	0.069	0.065	1.071	0.285	−0.058	0.197	0.003
				Medication condition	−0.509	0.177	−2.874	0.004	−0.859	−0.160	0.023
2	0.663b	0.009	0.652
				rs648893 (0 = aa, 1 = ag+gg)	0.198	0.187	1.062	0.289	−0.169	0.566	0.003
				rs2234918 (0 = aa, 1 = ag+gg)	−0.014	0.184	−0.075	0.940	−0.377	0.349	0.000
				rs1799971 (0 = aa, 1 = ag+gg)	0.191	0.187	1.023	0.307	−0.177	0.560	0.003
				rs678849 (0 = tt, 1 = ct+cc)	−0.121	0.203	−0.597	0.551	−0.520	0.278	0.001
				rs963549 (0 = cc, 1 = ct+tt)	−0.227	0.204	−1.113	0.267	−0.628	0.174	0.003
3	0.704c	0.010	0.621
				Medication × rs648893	0.443	0.387	1.145	0.253	−0.319	1.206	0.004
				Medication × rs2234918	0.395	0.379	1.041	0.299	−0.352	1.142	0.003
				Medication × rs1799971	0.260	0.384	0.677	0.499	−0.497	1.017	0.001
				Medication × rs678849	0.029	0.427	0.068	0.946	−0.812	0.869	0.000
				Medication × rs963549	−0.284	0.412	−0.689	0.491	−1.095	0.527	0.001

Note. Values represent the effects of the block of interest. Df numerator for all F-ratios = 5; df denominator =

^a266,

^b261,

^c256.

HDD=Heavy Drinking Days Per Week; ADS=Alcohol Dependence Scale; BAI=Beck Anxiety Inventory; AD criteria=current DSM-IV Alcohol Dependence criteria; Medication condition (0 = placebo, 1 = nalmefene).