Table 6.
Increase of midazolam Cmax and AUC after oral or peritoneal administration during concomitant posaconazole or ketoconazole therapy [54]
| Drug regimen | P.o. MDZ (2 mg) | I.v. MDZ (0.4 mg) |
|---|---|---|
| Posaconazole (200–400 mg) | MDZ Cmax: 2-fold increase | MDZ Cmax: 1.3–1.6-fold increase |
| MDZ AUC: 5-fold increase | MDZ AUC: 5–6-fold increase | |
| Ketoconazole (400 mg) | MDZ Cmax: 3-fold increase | MDZ Cmax: 1.6-fold increase |
| MDZ AUC: 8-fold increase | MDZ AUC: 8-fold increase |
AUC, area under the concentration–time curve; Cmax, maximum plasma drug concentration; i.v., intravenously; MDZ, midazolam; p.o., orally.