Table 7.
Major potential and confirmed drug interactions with different co-administered drugs and azole antifungal drugs [3]
| Fluconazole | Itraconazole | Voriconazole | Posaconazole | |
|---|---|---|---|---|
| Ciclosporin | ↑ | ↑ | ↑ | ↑ |
| Everolimus | ↑ | ↑↑ | ↑↑ | ↑↑ |
| Sirolimus | ↑ | ↑↑ | ↑↑ | ↑↑ |
| Tacrolimus | ↑ | ↑ | ↑↑ | ↑↑ |
| Calcium channel blockers | ↑ | ↑ | ↑ | ↑ |
| Antiarrhythmic agents (e.g. quinidine, dofetilide) | ↑ | ↑ | ↑ | ↑ |
| All-trans-retinoic acid | ↑ | ? | ? | ? |
| Busulfan | No | ↑ | ↑ | ? |
| Vinca alkaloids | ? | ↑ | ↑ | ↑ |
| Midazolam | ↑ | ↑ | ↑ | ↑ |
| Simvastatin | ↑ | ↑↑ | ↑↑ | ↑↑ |
| Rifampicin | ↓ FLU | ↓↓ ITR | ↓↓↓ VOR | ↓ POS |
| Phenytoin | ↑ | ↑ | ↑↑ | ↑ |
| ↓↓ FLU | ↓↓ ITR | ↓↓ VOR | ↓ POS | |
| Omeprazole | No | ↓↓ ITR (cap) | ↑ VOR | ↓ POS |
cap, capsule; FLU, fluconazole; ITR, itraconazole; POS, posaconazole; VOR, voriconazole. Table adapted from Lipp HP. Mycoses 2008; 51: 7–18, with permission [3].