Table 1B.
Comparison of noncompartment pharmacokinetic parameters across studies (statistics are arithmetic mean and %CV unless otherwise stated)
| Study number | Cmax (ng ml−1) | AUC(0,∞) (ng ml−1 h) | CL/F (l h−1) | Vz/F (l) | t1/2 (h) |
|---|---|---|---|---|---|
| 100 | 21.6 (31) | 633 (59) | 105 (57) | 2528 (41) | 20 (10–46) |
| 200 | 17.9 (38) | 623 (71) | 110 (48) | 3281 (38) | 25 (12–54)† |
| 300 | 18.3 (45) | 698 (95) | 142 (95) | 3340 (46) | 23 (8–52)† |
| 400 | 16.3 (37) | 440 (53) | 143 (52) | NR§ | 18 (29)‡ |
| 500 | 12.9 ± 9.3* | 353 ± 357* | 242 ± 131* | NR§ | 17 (11–38)† |
| 800 | 16.8 ± 6.6* | 516 ± 266* | 118 ± 53.5* | 3110 ± 1490* | 20 ± 7.2* |
| 900 | 20.5 (42)‡ | 768 (99)‡ | 65 (99)‡ | 2560 (38)‡ | 27 (15–159)† |
*
Mean ± SD.
†
Geometric mean (range).
‡
Geometric mean (%CV).
§
For some studies, no volume terms were reported (NR).