Table 2.
Population kinetic parameters for desipramine in plasma, assuming a two compartment model with first-order absorption and combined error model (base model with total clearance, absorption rate constant and volume of distribution)
| Parameter estimates | Between-subject variability | |||
|---|---|---|---|---|
| Parameter | Value | RSE* | CV (%) | RSE* |
| ka (h−1) | 0.15 | 17 | NA | NA |
| CL (l h−1) | 111 | 7 | 73 | 16 |
| V1 (l) | 1900 | 16 | 58 | 22 |
| Q (l h−1) | 58 | 13 | NA | NA |
| V2 (l) | 1050 | 13 | NA | NA |
| Plasma within-subject variability (ng ml−1) (additive error model) | 0.13 | 43 | ||
| Plasma within-subject variability (%) (proportional error model) | 37 | 7 | ||
*
Standard error expressed as percent coefficient of variation.