Table 3.
Population kinetic parameters for desipramine in plasma, assuming a two compartment model with first-order absorption and proportional error model (base model with intrinsic clearance, fraction unbound, bioavailability and blood-plasma ratio fixed)
| Parameter estimates | Between-subject variability | |||
|---|---|---|---|---|
| Parameter | Value | RSE* | CV (%) | RSE* |
| fu | 0.2 | – | – | – |
| R | 0.96 | – | – | – |
| ka (h−1) | 0.136 | 9 | NA | NA |
| CLint (l h−1) | 519 | 7 | 69 | 19 |
| V1 (l) | 974 | 12 | 91 | 19 |
| Q (l h−1) | 30 | 10 | NA | NA |
| V2 (l) | 595 | 9 | NA | NA |
| Plasma within-subject variability % (proportional error model) | 40 | 6 | ||
*
Standard error expressed as percent coefficient of variation; NA not assessed.