Table 5.
d-optimal population design for intermediate, extensive and ultrarapid metabolizers
| Design | Optimal sampling times (h) | |||||||
|---|---|---|---|---|---|---|---|---|
| Intermediate metabolizers | 0.25 | 0.25 | 24.25 | 24.25 | 24.25 | 73.25 | 75.25 | 199.25 |
| Extensive metabolizers | 0.25 | 0.25 | 19.25 | 19.25 | 19.25 | 58.25 | 90.25 | 199.25 |
| Ultrarapid metabolizers | 0.25 | 14.25 | 14.25 | 14.25 | 54.25 | 54.25 | 105.25 | 199.25 |
| CVSE* (%) | ||||||||
|---|---|---|---|---|---|---|---|---|
| ka | CLint | V1 | Q | V2 |  |
 |
σ | |
| Intermediate metabolizers | 28.5 | 12.6 | 20.4 | 19.9 | 14.3 | 43.3 | 44.8 | 19.1 |
| Extensive metabolizers | 18.2 | 9.3 | 16.2 | 16.8 | 9.8 | 38.5 | 36.9 | 18.0 |
| Ultrarapid metabolizers | 12.0 | 12.3 | 12.8 | 14.8 | 8.9 | 42.1 | 37.9 | 19.1 |
*
Coefficient of variation around the standard error. Exchange algorithm with step size 1 was used.