Table 1.
Up- and down-regulation of genes based on comparison of gene expression between experimental (cisplatin plus Curcuma longa (CL)-treated) and control (non-treated (NC) or cisplatin-treated (PC)) HEK 293 cells
| Regulation profile and fold change | |||||
|---|---|---|---|---|---|
| Genes | Probe ID | Symbol | NC | PC | CL |
| Up-regulated genes | |||||
| Cell proliferation-related genes | |||||
| Ecotropic viral integration site 5 | 208297_s_at | EVI5 | 1.7 | 1 | 4.5 |
| TBC1 domain family, member 8 (with GRAM domain) | 204526_s_at | TBC1D8 | 7.2 | 1 | 2.7 |
| DNA repair-related genes | |||||
| RAD23 homolog B (S. cerevisiae) | 214422_at | RAD23B | 1.5 | 1 | 2.7 |
| Down-regulated genes | |||||
| Immune and inflammatory response-related genes | |||||
| Chemokine (C-C motif) receptor 2 | 206978_at | CCR2 | 0.3 | 1 | 0.3 |
| C-type lectin domain family 4, member C | 1552552_s_at | CLEC4C | 1.1 | 1 | 0.2 |
| Dual oxidase 1 | 1565795_at | DUOX1 | 0.6 | 1 | 0.3 |
| Glutamate receptor, ionotropic, N-methyl D-aspartate 2B | 210412_at | GRIN2B | 0.9 | 1 | 0.5 |
| Interferon induced with helicase C domain 1 | 1555464_at | IFIH1 | 0.9 | 1 | 0.1 |
| Ras homolog gene family, member C | 235742_at | RHOC | 0.6 | 1 | 0.3 |
| Ribosomal protein L17 | 214291_at | hCG_2004593 | 0.9 | 1 | 0.5 |
| Tripartite motif-containing 13 | 1569142_at | TRIM13 | 0.3 | 1 | 0.5 |
| Apoptosis-related genes | |||||
| BCL2-like 11 (apoptosis facilitator) | 225606_at | BCL2L11 | 0.8 | 1 | 0.5 |
| CASP8 and FADD-like apoptosis regulator | 214618_at | CFLAR | 0.7 | 1 | 0.3 |
| Interleukin 1, alpha | 210118_s_at | IL1A | 0.3 | 1 | 0.4 |
| Programmed cell death 4 (neoplastic transformation inhibitor) | 1557166_at | PDCD4 | 1.5 | 1 | 0.3 |
| Programmed cell death 5 | 227751_at | PDCD5 | 1.2 | 1 | 0.2 |
| Pleckstrin homology-like domain, family A, member 1 | 217999_s_at | PHLDA1 | 0.9 | 1 | 0.3 |
| TNFRSF1A-associated via death domain | 1729_at | TRADD | 2.3 | 1 | 0.5 |
| IQ motif and WD repeats 1 | 224372_at | IQWD1 | 0.5 | 1 | 0.4 |
| Other | |||||
| Cytochrome P450, family 24, subfamily A, polypeptide 1 | 206504_at | CYP24A1 | 1.7 | 1 | 0.2 |