Table 2.
Successful base and covariate population pharmacokinetic models for MPA
| Model number | Covariate | Model | Compared against | OFV | ΔOFV | P |
|---|---|---|---|---|---|---|
| One compartment | ||||||
| 1 | Base model | CL = θ1× EXP(IIV + IOV) | −207.92 | |||
| V = θ2× EXP(IIV) | ||||||
| Two compartment | ||||||
| 2 | Base model | CL = θ1× EXP(IIV + IOV) | 1 | −457.85 | −249.93 | <0.001 |
| V1 = θ2× EXP(IIV) | ||||||
| Q = θ3× EXP(IIV) | ||||||
| V2 = θ4× EXP(IIV) | ||||||
| 3 | Bodyweight on CL | CL = θ1× (1 +θ7× WT/27.9) × EXP(IIV + IOV) | 2 | −475.25 | −17.40 | <0.001 |
| V1 = θ2× EXP(IIV) | ||||||
| Q = θ3× EXP(IIV) | ||||||
| V2 = θ4× EXP(IIV) | ||||||
| 4 | Concomitant ciclosporin on CL | CL = θ1× (1 +θ7× WT/27.9) × (1 +θ8× CYTA) × EXP(IIV + IOV) | 3 | −497.63 | −22.38 | <0.001 |
| V1 = θ2× EXP(IIV) | ||||||
| Q = θ3× EXP(IIV) | ||||||
| V2 = θ4× EXP(IIV) |
OFV, NONMEM derived objective function value; WT, bodyweight; CYTA, concomitant ciclosporin (CYTA = 0 if the patient taking ciclosporin, CYTA = 1 if without ciclosporin while taking tacrolimus); CL, clearance; Q, inter-compartmental clearance; V1, volume of distribution in the central compartment; V2, volume of distribution in the peripheral compartment. The population CL term was standardized to 27.9 kg, which represents the median value of weight in this study group.