. 2010 Oct;70(4):567–579. doi: 10.1111/j.1365-2125.2010.03734.x

Table 4.

The percentage of children who achieved total MPA AUC(0,24 h) values below, within and above the daily target range of a 60–120 mg l⁻¹ h, calculated by 1000 simulations for children with different bodyweights and concomitant ciclosporin (tacrolimus) when given 10 mg kg⁻¹ intravenous infusion or oral doses of MMF

Intravenous infusion or oral MMF 10 mg kg⁻¹
Weight	Concomitant treatment with ciclosporin
	Intravenous infusion MMF three times daily			Oral MMF three times daily
	Total MPA AUC(0,24 h) (mg l⁻¹ h)			Total MPA AUC(0,24 h) (mg l⁻¹ h)
	<60 mg l⁻¹ h	60–120 mg l⁻¹ h	>120 mg l⁻¹ h	<60 mg l⁻¹ h	60–120 mg l⁻¹ h	>120 mg l⁻¹ h
10 kg	99.7%	0.3%	0.0%	99.4%	0.5%	0.1%
25 kg	84.0%	15.8%	0.2%	94.8%	4.7%	0.5%
50 kg	52.1%	46.3%	1.6%	87.3%	11.4%	1.3%
	Concomitant treatment with tacrolimus
	Intravenous infusion MMF twice daily			Oral MMF twice daily
	Total MPA AUC(0,24 h) (mg l⁻¹ h)			Total MPA AUC(0,24 h) (mg l⁻¹ h)
	<60 mg l⁻¹ h	60–120 mg l⁻¹ h	>120 mg l⁻¹ h	<60 mg l⁻¹ h	60–120 mg l⁻¹ h	>120 mg l⁻¹ h
10 kg	87.4%	12.5%	0.1%	95.4%	4.2%	0.4%
25 kg	24.6%	69.9%	6.5%	77.9%	19.1%	3.0%
50 kg	6.0%	66.7%	27.3%	62.7%	30.2%	7.1%

Note:Target ranges for total MPA AUC(0,12 h) are 30–60 mg l⁻¹ h [21, 26]. A derived target range for total MPA AUC(0,24 h), 60–120 mg l⁻¹ h was used in the present study as the simulated doses were administered twice or three times daily.