. 2010 Oct;70(4):567–579. doi: 10.1111/j.1365-2125.2010.03734.x

Table 5.

The percentage of children who achieved total MPA AUC(0,24 h) values below, within and above the daily target range of a 60–120 mg l⁻¹ h, calculated by 1000 simulations for children with different bodyweights and concomitant ciclosporin (tacrolimus) when given 15 mg kg⁻¹ intravenous infusion or oral MMF

Intravenous infusion or oral MMF 15 mg kg⁻¹
Weight	Concomitant treatment with cyclosporine
	Intravenous infusion MMF three times daily			Oral MMF three times daily
	Total MPA AUC(0,24 h) (mg l⁻¹ h)			Total MPA AUC(0,24 h) (mg l⁻¹ h)
	<60 mg l⁻¹ h	60–120 mg l⁻¹ h	>120 mg l⁻¹ h	<60 mg l⁻¹ h	60–120 mg l⁻¹ h	>120 mg l⁻¹ h
10 kg	92.9%	7.1%	0.0%	96.7%	3.2%	0.1%
25 kg	38.1%	58.8%	3.1%	83.5%	14.6%	1.9%
50 kg	12.0%	71.7%	16.3%	70.4%	24.3%	5.3%
	Concomitant treatment with tacrolimus
	Intravenous infusion MMF twice daily			Oral MMF twice daily
	Total MPA AUC(0,24 h) (mg l⁻¹ h)			Total MPA AUC(0,24 h) (mg l⁻¹ h)
	<60 mg l⁻¹ h	60–120 mg l⁻¹ h	>120 mg l⁻¹ h	<60 mg l⁻¹ h	60–120 mg l⁻¹ h	>120 mg l⁻¹ h
10 kg	43.4%	54.0%	2.6%	84.9%	13.4%	1.7%
25 kg	2.8%	56.1%	41.1%	55.7%	33.7%	10.6%
50 kg	0.4%	23.8%	75.8%	40.1%	37.5%	22.4%

Note:Target ranges for total MPA AUC(0,12 h) are 30–60 mg l⁻¹ h [21, 26]. A derived target range for total MPA AUC(0,24 h), 60–120 mg l⁻¹ h was used in the present study as the simulated doses were administered twice or three times daily.