Table 1.
IGF-1 and Cytokine Levels in LID Versus Wild-Type Mice 20 wk After the Last AOM Injection
| Cytokine | LID mice (n = 24), mean (SD) |
Wild-type mice (n = 11), mean (SD) |
P-valuea |
|---|---|---|---|
| IGF-1 | 75.37 (4.25) | 163.33 (21.45) | <0.0001 |
| GM-CSF | 218.67 (14.59) | 307.74 (15.35) | 0.0008 |
| IFN-γ | 65.78 (43.86) | 100.45 (3.37) | 0.0001 |
| IL-1β | 18.31 (2.61) | 33.36 (7.58) | 0.0296b |
| IL-2 | 39.69 (11.15) | 56.54 (22.31) | 0.4665 |
| IL-4 | 7.60 (0.42) | 11.75 (0.45) | <0.0001 |
| IL-5 | 16.11 (1.89) | 30.82 (4.12) | 0.0007 |
| IL-6 | 46.68 (8.57) | 56.92 (9.50) | 0.4775 |
| IL-10 | 199.59 (16.99) | 427.38 (52.21) | <0.0001 |
| IL-12 | 401.60 (47.55) | 645.49 (29.15) | 0.0028 |
| TNF-α | 6.31 (0.65) | 11.28 (1.55) | 0.0015 |
a
P-values were calculated via a Student's t-test.
b
The P-value for IL-1β does not remain significant after adjustment for multiple comparisons using Bonferroni correction.