Table II. IR-induced muscle injury and MC degranulation in mice deficient in LTC4S, PGD2S, and mMCP-1 compared to their wild-type controls.
| Mouse Strain | Muscle Injurya | No. of Intact MCb | ||
|---|---|---|---|---|
| IR treated | Sham treated | IR treated | Sham treated | |
| LTC4S−/− | 42.0 ± 0.6 | 0 | 2.7 ± 0.9 | 21 |
| C57BL/6 | 40.7 ±1.2 | 0 | 3.7 ± 0.3 | 22 |
| PGD2S−/− | 36.0 ± 4.0 | 2.0 ± 2.0 | 4.3 ± 0.9 | 19.5 ± 1.5 |
| C57BL/6 | 23.8 ± 4.4 | 1.0 ± 1.0 | 10.0 ± 1.1 | 21.5 ±1.5 |
| mMCP-1−/− | 21.4 ±1.5 | 0.0 ± 0.0 | 12.6 ± 1.5 | 23.5 ± 2.5 |
| BALB/c | 17.3 ± 0.9 | 0.0 ± 0.0 | 13.0 ± 2.5 | 22.0 ±3.0 |
a
Values are the mean number (±SEM or one-half range for two animals) of injured muscle fibers (per 50 fc) quantitated histologically from: 3 LTC4S −/− and 3 +/+ mice in the IR-treated groups with 1 sham from each strain; 4 PGD2S−/− and 4 +/+ IR-treated mice with 2 shams each; 5 mMCP-1 −/− and 5 +/+ IR-treated mice with 2 shams each.
b
Values are the mean number (±SEM or one-half range for two animals) of intact MCs per 20 LPF from the same animals.