Fig. 6.

Immunohistochemical staining of eosinophilic major basic protein (MBP) demonstrating that OVA/UFP challenge induced more severe allergic inflammation in the alveolar ducts (ad) and alveoli (a) than in the proximal axial airway (aa; generation 5) in OVA/UFP-sensitized mice. A and B: OVA sensitization followed by OVA/FA challenge. C and D: OVA sensitization followed by OVA/UFP challenge. E and F: OVA/UFP sensitization followed by OVA/FA challenge. G and H: OVA/UFP sensitization followed by OVA/UFP challenge. Respiratory epithelium lining axial airway, ep; pulmonary artery, pa; blood vessel, bv. Arrows indicate positive staining of MBP in eosinophils.