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. 2010 Jun 11;299(3):L334–L344. doi: 10.1152/ajplung.00017.2010

Fig. 6.

Fig. 6.

Vascular effects of NGF inhibition. Pretreatment with anti-NGF antibody markedly reduced neurogenic Evans blue exudation in the airways of PAO1-infected weanling rats, and even stronger inhibition was noted after chemical inhibition of tropomyosin-related kinase (Trk) signaling with K252a. After NGF blockade, Evans blue exudation in the respiratory tract of weanling rats infected with PAO1 was not significantly different from age-matched noninfected controls. Means ± SE (n = 6–8 rats per group). **P < 0.01 compared with noninfected controls; ##P < 0.01 compared with infected rats with intact NGF activity.