Fig. 9.

Effect of NGF inhibition on cytokines/chemokines. Neurotrophin inhibition with the specific blocking antibody or with K252a, which blocks Trk signaling, decreased significantly the concentrations of eotaxin, leptin, IL-18, and IL-1β in BAL specimens from PAO1-infected weanling rats, returning their values to noninfected control levels. A similar trend was also observed for TNF-α, but this effect was statistically significant only with the anti-NGF antibody. Means ± SE (n = 4–7 rats per group). **P < 0.01, ***P < 0.001 compared with noninfected controls; #P < 0.05, ##P < 0.01, ###P < 0.001 compared with infected rats with intact NGF activity.