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Immunolocalization of ET-1 in control, heritable pulmonary artery hypertension (HPAH), and idiopathic PAH (IPAH) (as a disease control) lungs. ET-1 localizes in alveolar macrophages in control (A), HPAH (B), and IPAH (C) as denoted by arrows. ET-1 also localizes in ECs and SMCs from pulmonary arteries in control (D and E), HPAH with BMPR2 mutation (F and G), and IPAH (H) as denoted by arrows. Magnification, ×400.
