Fig. 6.
Immunolocalization of ETA and ETB receptors in control, HPAH, and IPAH lungs. I: ETA receptors localize in alveolar macrophages in control (A) and IPAH (C). In lung, macrophages from HPAH localization of ETA receptor is decreased (B). Expression of ETA is denoted by arrows in macrophages. ETA receptor also localizes in SMCs from pulmonary arteries in control (D and E), HPAH (F and G), and IPAH (H and I) as denoted by arrows. II: ETB receptor localizes in alveolar macrophages in control (A) and IPAH (C). In macrophages from HPAH, localization of ETB receptor is decreased (B). Expression of ETB receptor is denoted by arrows in macrophages. ETB receptor was also localized in pulmonary artery ECs in control (D and E), HPAH (F and G), and IPAH (H and I) as denoted by arrows and in pulmonary artery SMCs from control (D and E), HPAH (F and G), and IPAH (H and I) as denoted by arrows. Magnification, ×400.