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Analysis of the reaction kinetics of the 2 reactive centers in glutathione
| Reaction | k2 (M−1s−1) | kapp (M−1s−1) |
|---|---|---|
| RS− + HOCl | 1.2 × 109 | 1.8 × 107 |
| RS− + OCl− | 1.9 × 105 | |
| RNH2 + HOCl | 3.4-5.4 × 107 | ∼1 × 105 |
| RS− + Cl2 | ∼1 × 1010 | ∼2 × 108 |
| RNH2 + Cl2 | 1.0 × 109 | 2.5 × 106 |
The apparent second order rate constant kapp was calculated for 25°C and pH 7 using values of 8.7 and 9.6 for the pKa of the thiol and γ-glutamyl residue α-amino groups in GSH; 7.54 was used for the pKa of HOCl.
