Table 3.
Bone length and mechanical strength of the femur and tibia of mice during ex vivo three-point testing.
| Parameters, (units) | Treatments | |||||
|---|---|---|---|---|---|---|
| SHM | OVX | S + V | O + G | SVG | P-value | |
| Right Femur | (n = 11) | (n = 12) | (n = 8) | (n = 14) | (n = 9) | |
| Bone length, (mm) | 15.81 ± 0.02b | 16.26 ± 0.02a | 15.92 ± 0.02ab | 16.22 ± 0.03a | 15.76 ± 0.03b | <.0001 |
| Ultimate Force, (N) | 16.0 ± 0.3a | 13.4 ± 0.3b | 16.1 ± 0.6a | 15.7 ± 0.5a | 16.6 ± 0.3a | <.0001 |
| Failure Force, (N) | 12.1 ± 1.1a | 5.8 ± 1.0b | 9.6 ± 1.7ab | 9.0 ± 1.1ab | 11.7 ± 1.7a | <0.010 |
| Yield Force, (N) | 12.3 ± 0.6a | 10.3 ± 0.4b | 12.2 ± 0.4ab | 11.9 ± 0.6ab | 12.0 ± 2.6ab | <0.001 |
| Stiffness, (N/mm) | 81.4 ± 1.4 | 75.8 ± 2.7 | 80.2 ± 3.1 | 83.0 ± 2.4 | 84.4 ± 1.2 | NS |
| Energy to Ultimate Force, (mJ) | 3.1 ± 0.1 | 2.7 ± 0.2 | 3.0 ± 0.2 | 3.0 ± 0.2 | 3.3 ± 0.1 | NS |
|
| ||||||
| Left Tibia | (n = 11) | (n = 15) | (n = 12) | (n = 18) | (n = 10) | |
| Bone length, (mm) | 18.08 ± 0.07bc | 18.38 ± 0.06a | 18.26 ± 0.03abc | 18.33 ± 0.06ab | 18.07 ± 0.04c | <0.001 |
| Ultimate Force, (N) | 10.5 ± 0.2 | 9.8 ± 0.2 | 10.6 ± 0.2 | 10.4 ± 0.3 | 10.7 ± 0.4 | NS |
| Failure Force, (N) | 4.9 ± 0.9 | 3.7 ± 0.6 | 3.3 ± 0.3 | 4.5 ± 0.6 | 3.7 ± 0.8 | NS |
| Yield Force, (N) | 10.0 ± 0.2 | 9.1 ± 0.3 | 10.3 ± 02 | 9.9 ± 0.3 | 10.2 ± 0.4 | NS |
| Stiffness, (N/mm) | 36.2 ±1.1 | 35.8 ± 0.8 | 39.1 ±1.1 | 37.4 ± 0.8 | 38.5 ± 0.9 | NS |
| Energy to Ultimate Force, (mJ) | 2.0 ± 0.1 | 1.8 ± 0.1 | 1.8 ± 0.1 | 1.9 ± 0.1 | 1.9 ± 0.1 | NS |
Data represent the group means ± SEM. Different letters indicate means that are statistically different. NS indicates not significant. Samples that rolled on the supports during mechanical testing were eliminated from the analyses.