Table 3.
Activation patterns in response to facial expressions relative to neutral in pediatric OCD subjects and healthy comparison subjects (HC)
| All Emotion | Fear | Disgust | Happy | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| XYZ | Z | k | XYZ | Z | k | XYZ | Z | k | XYZ | Z | k | |
| HC > OCD | ||||||||||||
| OFC | −16, 10, −16 | 3.12 | 31 | |||||||||
| OCD>HC | ||||||||||||
| VLPFC | −32, 30, −6 | 3.85 | 30 | |||||||||
| DACC | −2,44, 24 | 3.38 | 20 | |||||||||
| HC Activations | ||||||||||||
| Amygdala | 28,6, −22 | 3.74 | 40 | 28, 6, −24 | 3.19 | 23 | ||||||
| −16,−6, −24 | 3.12 | 11 | ||||||||||
| Insula | −22, 28, −10 | 4.19 | 12 | |||||||||
| OCD Activations | ||||||||||||
| Amygdala | −32, 2, −24 | 3.25 | 14 | |||||||||
| HC Deactivations | ||||||||||||
| VLPFC | −42, 42, −4 | 3.64 | 24 | −40, 40, −6 | 4.47 | 65 | −42, 28, −12 | 3.58 | 221 | |||
Significant clusters at p<0.05 corrected using a cluster level (>7 voxels) for the amygdala and (>12 voxels) for the orbitofrontal cortex (OFC), ventrolateral prefrontal cortex (VLPFC), dorsal anterior cingulate (dACC), and insula.
MNI coordinates provided. k=cluster values at p<0.005 peak threshold for amygdala and p<0.001 peak threshold for all other regions.