TABLE 1.
Medical Examiner cases with significant neuropathological lesions.
| ID # | Age | Phf1 |
NFT/ Thio-S |
PL/ Thio-S |
Tdp43 |
Possible NP DX |
||||
|---|---|---|---|---|---|---|---|---|---|---|
| CA | EC | CA | EC | CA | EC | CA | EC | |||
| 18 | 74 | 3 | 3 | 3 | 3 | 2 | 3 | 0 | 0 | AD |
| 29 | 66 | 2 | 3 | 3 | 2 | 3 | 3 | 0 | 0 | AD |
| 59 | 79 | 3 | 2 | 2 | 2 | 2 | 3 | 2 | 0 | AD |
| 60 | 91 | 3 | 3 | 3 | 3 | 3 | 3 | 0 | 0 | AD |
| 63 | 72 | 3 | 3 | 2 | 2 | 2 | 2 | 0 | 0 | AD |
| 64 | 80 | 2 | 3 | 2 | 3 | 2 | 2 | 0 | 0 | AD |
| 65 | 83 | 2 | 3 | 2 | 2 | 2 | 3 | 0 | 0 | AD |
| 95 | 89 | 3 | 3 | 3 | 3 | 2 | 3 | 0 | 0 | AD |
| 96 | 73 | 3 | 3 | 2 | 2 | 3 | 3 | 0 | 0 | AD |
| 12 | 77 | 3 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | Tau |
| 24 | 79 | 3 | 3 | 2 | 2 | 0 | 0 | 0 | 0 | Tau |
| 62 | 58 | 3 | 3 | 2 | 3 | 0 | 0 | 0 | 0 | Tau |
| 77 | 83 | 3 | 2 | 0 | 1 | 0 | 0 | 0 | 0 | Tau |
0,1,2,3 represent degree of pathology. Phf1 (paired helical filaments), TDP-43: pathology visualized by immunohistochemistry with antibody against tau or TDP-43.
Thio-S, pathology visualized by Thio-S histochemistry; CA, cornu ammonis; EC, entorhinal cortex; PL/Thio-S, plaques with Thioflavin-S reactivity; AD, Alzheimer's disease; NFT, neurofibrillary tangles; Tau, frontotemporal lobar degeneration tauopathy; Tdp43, Tar DNA-binding protein-43.