FIGURE 5.

β-LGND2 alters body composition of OVX mice. Six-week-old C57BL6 female mice (n = 8) were either sham-operated and treated with vehicle on ovariectomized mice and treated with vehicle or 30 mg/kg/day β-LGND2 subcutaneously for 9 weeks. MRI scan was performed at day 0 and week 9 to determine the fat mass (A, left panel) and lean mass (A, right panel). After 9 weeks, the mice were sacrificed and weights of white adipose tissue and uterus (B) were recorded. Veh, vehicle; *, significance at p < 0.05 from normal diet-fed vehicle-treated animals; #, significance at p < 0.05 from high-fat diet-fed vehicle-treated animals.