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Docking of G6 and its derivatives into the ATP-binding pocket of Jak2. G6 (pink) and its stilbenoid derivatives D28 (gray) and D30 (yellow) showed hydrogen bond interactions (<3.5 Å) with several critical residues (Glu930, Leu932, Arg980, and Asp994) that make up the ATP-binding pocket of Jak2. However, the nonstilbenoid derivatives D21 (magenta), D23 (orange), and D25 (yellow) show no such hydrogen bond interactions.
