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. 2010 Jul 23;285(41):31491–31501. doi: 10.1074/jbc.M109.068387

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© 2010 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 5. — Knockdown of FOXO3A and/or overexpression of miR-17-5p delay cellular senescence. A, quantitative RT-PCR detects miR-17-5p level after transfecting miR-17-5p duplex (17-5p-DP) into 2BS cells. B, cell proliferation assay of oncogenically stressed (RasV12-expressing) 2BS cells with knockdown of FOXO3A and/or overexpression of miR-17-5p, FOXO3A knockdown (upper panel), miR-17-5p overexpression (middle panel), FOXO3A knockdown, and miR-17-5p overexpression (lower panel). Cells were fixed and stained 9 days after infection. C, samples from B were analyzed for IL6 and IL8 transcript levels by qRT-PCR. Levels are normalized to actin expression and represented as means ± S.D.