FIGURE 8.
Conversion from p53 arrester to p53 killer after DNA damage. ksp21 is the p53-inducible synthesis rate of p21, and kre is the association constant between E2F1 and Rb. A, displayed is the conversion in the normal case (with ksp21 = 0.07 and kre = 2) at DIR = 5 Gy. Displayed are time courses of [p53 arrester] (black) and [p53 killer] (red) (top panel), [p21] (black) and [E2F1] (red) (middle panel), [Wip1] (black) and [p53DINP1] (red) (bottom panel). B, shown are time courses of [p53 arrester] (black), [p53 killer] (red), and [E2F1] (blue) with ksp21 = 0 and DIR = 2 Gy. C, the same conventions is used as in panel B with ksp21 = 0.1 and DIR = 12 Gy. D, shown is the number of p53 arrester pulses required for producing one pulse of p53 killer, narrester, as a function of ksp21. E, the same convention is used as in panel B with kre = 0.1, IS = 0.4 and DIR = 2 Gy.