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. 2010 Jul 29;285(41):31590–31602. doi: 10.1074/jbc.M110.101584

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© 2010 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 8. — Model for the role of Rab32 in MAM enrichment and PKA localization. Rab32 regulates the equilibrium between peripheral and perinuclear (MAM) calnexin (CNX). Active Rab32 (Q85L) extracts calnexin from the MAM and redistributes it to the cellular periphery. Rab32 also mediates the distribution of PKA between the cellular periphery, where it regulates melanosome biogenesis (43), and the perinuclear area, where it regulates apoptosis onset (this study). Substrates that are PKA-phosphorylated and dependent on Rab32 activity and expression levels include but are not limited to Bad and Drp1.