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Analysis of the binding affinity of WT SET7/9 and its catalytic mutants for unmodified and methylated TAF10 peptides
| SET7/9 | TAF10 peptide | KDa |
|---|---|---|
| μm | ||
| WT | K189 | 4.9 ± 0.20 |
| WT | K189me1 | 4.0 ± 0.36 |
| Y305F | K189 | 1.3 ± 0.10 |
| Y305F | K189me1 | 0.62 ± 0.065 |
| Y305Fb | K189me2 | >70 |
| Y245A | K189 | 4.0 ± 0.25 |
| Y245A | K189me1 | 3.3 ± 0.10 |
| Y245A | K189me2 | 5.8 ± 0.22 |
| Y245A | K189me3 | 11 ± 0.28 |
a Curve fitting errors were calculated from the binding isotherms.
b An estimate of the affinity is reported due to weak peptide binding.
