TABLE 2.
Demographic and Immunocytochemical Characteristics of the 12 Chronic Traumatic Encephalopathy Cases
| Case | Demographics |
Tau Immunoreactivity |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MND | Age, Years | Sex | Sport | Race | APOE | Spinal Cord | Brainstem | Diencephalon | Basal Ganglia | Medial Temporal Lobe | Frontal, Insular, and Temporal Cortex | Aβ | |
| 1* | Yes | 66 | M | PFB | C | 2/3 | +++ | +++ | +++ | ++ | +++ | +++ | 0 |
| 2* | Yes | 49 | M | PFB | AA | 3/4 | + | ++ | + | + | + | + | + |
| 3* | Yes | 67 | M | PB | C | 3/3 | +++ | +++ | +++ | +++ | +++ | +++ | + |
| 4† | No | 73 | M | PB | C | 3/3 | + | +++ | +++ | +++ | +++ | +++ | 0 |
| 5† | No | 82 | M | PFB | C | 3/3 | + | +++ | +++ | ++ | +++ | +++ | 0 |
| 6* | No | 75 | M | PH | C | 3/4 | ++ | +++ | ++ | ++ | ++ | ++ | ++ |
| 7* | No | 85 | M | PFB | C | 3/3 | + | + | + | + | +++ | +++ | ++ |
| 8† | No | 80 | M | PB | AA | 3/4 | + | +++ | + | + | +++ | +++ | ++ |
| 9† | No | 76 | M | PB | AA | NA | NA | +++ | + | + | +++ | ++ | ++ |
| 10‡ | No | 42 | M | PFB | C | 3/3 | NA | + | + | + | ++ | +++ | 0 |
| 11‡ | No | 45 | M | PFB | C | 4/4 | NA | + | + | + | ++ | +++ | 0 |
| 12‡ | No | 45 | M | PFB | C | 4/4 | NA | + | + | + | ++ | +++ | + |
*
Entire spinal cord studied.
†
Cervical spinal cord only studied.
‡
No spinal cord tissue available for study.
Tau immunoreactivity rated on a semiquantitative 0–3 scale: 0, absent; +, mild; ++, moderate; +++, severe; NA, data not available; Aβ, β-amyloid; M, male; MND, motor neuron disease; APOE, apolipoprotein E; PFB, professional football; PB, professional boxing; PH, professional hockey; C, white; AA, African American.