. Author manuscript; available in PMC: 2010 Oct 7.

Published in final edited form as: J Neuropathol Exp Neurol. 2010 Sep;69(9):918–929. doi: 10.1097/NEN.0b013e3181ee7d85

TABLE 3.

TDP-43 Immunoreactivity in the 12 Athletes With Chronic Traumatic Encephalopathy

Case	MND	TDP-43 Immunoreactivity
Case	MND	Spinal Cord	Medulla	Midbrain	Basal Ganglia	Diencephalon	Frontal Cortex	Rolandic Cortex	Insula	Temporal Cortex	Subcortical White Matter	Medial Temporal Lobe	Dentate Gyrus
1^*	Yes	+++	++	+++	+	++	++	+++	++	++	++	++	0
2^*	Yes	+++	++	+++	+	++	++	+++	++	++	++	++	0
3^*	Yes	++	+	+++	++	++	++	++	++	++	++	++	r
4^†	No	+	+	+++	++	++	+	+	+	+	+++	++	r
5^†	No	0	+	+	+	++	++	++	++	+++	+	+	r
6^*	No	0	+	0	+	0	0	0	0	0	0	++	0
7^*	No	0	0	+	0	0	+	+	+	+++	+	+	0
8^†	No	0	+	+	++	+	+	+	+	+	+	++	r
9^†	No	NA	++	++	+	+	0	0	0	0	0	+	0
10^‡	No	NA	NA	+	0	0	0	0	0	0	0	0	0
11^‡	No	NA	NA	0	0	0	0	0	0	0	0	0	0
12^‡	No	NA	NA	0	0	0	0	0	0	0	0	0	0

Entire spinal cord studied.

^†

Cervical spinal cord only studied.

^‡

No spinal cord tissue available for study.

TDP-43 immunoreactivity rated on a semiquantitative 0–4 scale: 0, absent; r, rare; +, mild; ++, moderate; +++, severe; NA, data not available; MND, motor neuron disease.