Table 4.

Proportional hazards regression estimates of time to death-censored graft failure based on inflammation status: iatr only (i=0, iatr>0), and iatr or i ≥0 relative to no inflammation (i = 0 iatr = 0) adjusted for serum creatinine at time of biopsy, and extent of inflammation (i), atrophy (ct), fibrosis (ci), C4d positivity (C4d⁺) and Donor Specific Antibody positivity (DSA⁺).

	Hazard Ratio [95% Confidence Interval]; P-value
Group	Model 1 Adjusted for serum creatinine	Model 2 Adjusted for ci and serum creatinine	Model 3 Adjusted for ct and serum creatinine	Model 4 Adjusted for C4d+, DSA+ and serum creatinine	Model 5 Adjusted for C4d+, DSA+, ci and serum creatinine	Model 6 Adjusted for C4d+, DSA+, ct and serum creatinine
No inflammation [i=0, iatr=0]	REF*	REF	REF	REF	REF	REF
iatr only [i=0, iatr>0]	3.06 [1.51,6.19]; 0.0018	2.31 [1.10,4.83]; 0.0262	2.42 [1.16,5.08]; 0.0191	5.06 [1.71,14.97]; 0.0034	3.70 [1.21,11.34]; 0.0221	4.02 [1.28,12.60]; 0.0170
Inflammation [i>0, iatr≥0]	2.10 [1.09,4.06]; 0.0268	1.60 [0.81,3.17]; 0.1780	1.51 [0.76,3.01]; 0.2367	2.88 [1.02,8.07]; 0.0448	2.35 [0.84,6.63]; 0.1052	2.35 [0.82,6.70]; 0.1105

^*REF= reference group