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. Author manuscript; available in PMC: 2011 Sep 1.
Published in final edited form as: J Neurochem. 2010 Jul 27;114(6):1781–1791. doi: 10.1111/j.1471-4159.2010.06890.x

Fig. 2. D2 receptor regulation of striatal DA release is enhanced in Phe(+) mice.

Fig. 2

A.Representative records of 1 p evoked [DA]o in a non-Tg mouse under control conditions and in increasing concentrations of the D2 receptor agonist, quinpirole (1 nM to 10 μM). B. Mean concentration-response curves for the inhibition of DA release by quinpirole in non-Tg, Phe(−) and Phe(+) mice. Values are expressed as % inhibition of DA release (mean ± SEM, n = 5 for each group) against log concentrations of quinpirole; dashed lines indicate the quinpirole concentration at which peak 1 p evoked [DA]o was inhibited by 50%. Actual IC50 and Imax values for each group (see Table 1) were calculated from fitting one-component sigmoidal curves to concentration-response data from individual experiments.