Figure 1. Solution structure of the I214V mutant of RaPrP^C(91–228).

(A) Diagram of 15 lowest-energy conformations. (B) Ribbon cartoon showing the secondary structure elements of the mean structure. (C) Sausage diagram showing the superposition of structures of the wild-type (grey) and the mutant (pink). The structure was determined in acetate buffer at pH 4.5. The diagrams are generated using MolMol [61].