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. 2010 Oct 7;5(10):e13187. doi: 10.1371/journal.pone.0013187

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Keenan et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Phase contrast image of a symmetrically dividing hNPC which comprised 77.5% of all divisions. (B) The cell retracts all processes and rounds up. (C) Division and cytokinesis occurs on a plane perpendicular to the former major axis of the mother cell. (D) Daughter cells are morphologically indistinguishable from one another. (E) Phase contrast image of an asymmetrically dividing hNPC which comprised 22.5% of all divisions in 2D dissociated cultures. (F) The cell rounds up but does not fully retract its major process. (G) The cell divides along a plane approximately parallel to the cell’s major axis. (H) One daughter cell maintains the radial process while the other adopts a MC morphology. Scale bar = 25 um.