Figure 2. Comparison of DotDĪN with secretin periplasmic subdomains.
(A) DotD (green) superimposed onto the N0 domain of ETEC secretin GspD (residue 43 to 120; PDB accession 3ezj) from the type II secretion system (blue). (B) DotD (green) superimposed onto the T3S domain of EPEC secretin EscC (residue 21 to 103; PDB accession 3gr5) from the type III secretion system (light blue). (C) Structure-based sequence alignment of the DotD domain, GspD and EscC. Conserved residues are colored. See text for explanations for yellow shaded residues and residues shown in italics.