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Secondary structure of the peptidyl transferase center in E. coli 23S rRNA. The site of erythromycin resistance methylation at A2058 is shown in red. Key nucleotide interactions (blue) that support antibiotic binding are the same in T. thermophilus but different in H. halobium rRNA. D. radiodurans rRNA has C752 (21) and thus lacks the 752–2609 bp onto which the telithromycin heterocycles would stack.
