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. 2010 Sep 20;107(40):17391–17396. doi: 10.1073/pnas.1008025107

Fig. 6.

Fig. 6.

Effects of icv leptin delivery in insulin-deficient mice quickly vanish after leptin withdrawal (WD). (A) Oral glucose tolerance test (2 g/kg of body weight) in T1D-icv-Leptin-50 mice 10 d after surgery. Glycemia levels (Left) and insulin levels (Right) in the blood. ND, below the threshold of detection. (B) Glycemia before and after icv leptin administration was interrupted in T1D-icv-Leptin-50 mice. WD1, WD2, and WD3 in the x axis indicate 1, 2, and 3 d after leptin administration was interrupted, respectively. Error bars represent SEM (n = 7).