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. 2010 Sep 20;107(40):17374–17378. doi: 10.1073/pnas.1008533107

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Fig. 5. — Light stimulates movement in Opn4^+/+ and Opn4^+/− pups, but not in Opn4^−/− littermates. Movement was quantified as the distance the centroid of the pup's image traveled during the 60 s test periods (Materials and Methods). Mice were placed in the chamber for periods of 2–5 min in darkness. Distances during the 60-s period before (dark bars) and after light onset (light bars) are plotted for Opn4^+/+ (n = 11), Opn4^+/− (n = 20), and Opn4^−/− (n = 9) mice. Results from P7–P9 aged animals are grouped together. Statistically significant differences between light and dark were observed in the Opn4^+/+ and Opn4^+/− mice (P < 0.001). No statistically significant light–dark differences were observed in the Opn4^−/− mice (P > 0.05). Posttest analysis (Bonferroni) revealed no statistical differences between distances traversed in darkness of ^+/+, ^+/−, or ^−/− littermates. Error bars represent SEM.