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Plakoglobin regulates Src activity through ECM deposition. (A) Western blot analysis of the levels of activated Src [Src(Tyr416-P); Scr-p416] in PG+/− and PG−/− keratinocytes in steady state. (B) Western blot showing a decrease in activated Src in PG−/− cells on the ECM deposited by PG+/− cells 5 hours after replating. (C) Immunofluorescence showing more robust focal adhesions in PG−/− cells treated with the Src inhibitor PP2. Scale bar: 20 μm.
