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Characterization of AD-PHF and tau filaments by TEM. Filaments obtained from recombinant tau protein induced by 200 μM heparin (A) and AD-PHF from AD patients (B) were characterized by transmission electronic microscopy (TEM). In these macrographs, yellow arrowheads point torsion of the polymers. In the preparations obtained from AD patients, single straight filaments were predominant as compared with the PHF preparation where PHF are predominant (Bars = 80 nm).
