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Brain penetration as analyzed by LogP and PAMPA assays for astemizole and lansoprazole
| Drug | PAMPA (Pe) (cm/s) | PAMPA CNS permeability | Log P (oct/PBS pH7,4) | Log P CNS permeability |
|---|---|---|---|---|
| astemizole | 1.447* 10−4 | + | 5.57 | ++ |
| lansoprazole | 3.63* 10−5 | + | 1.47 | ++ |
| Clidinium bromide | 0.0029* 10−5 | − | −0.092 | −− |
| Tiopenthal | 1.7* 10−5 | + | 1.4 | + |
