Table 4.
Rresults of loss of heterozygosity in 51 gastrointestinal stromal tumors according to Fletcher’s classification
| Risk classification |
1751 |
1846 |
9421 |
1748 |
||||||||
| LOH (n) | Hetero-zygosity (n) | Rate (%) | LOH (n) | Hetero-zygosity (n) | Rate (%) | LOH (n) | Hetero-zygosity (n) | Rate (%) | LOH (n) | Hetero-zygosity (n) | Rate (%) | |
| Very low and low | 2 | 7 | 22.2 | 3 | 6 | 33.3 | 3 | 9 | 25.0 | 1 | 9 | 10.0 |
| Intermediate | 2 | 5 | 28.6 | 4 | 7 | 36.4 | 4 | 8 | 33.3 | 2 | 8 | 20.0 |
| High | 6 | 5 | 54.5 | 5 | 7 | 41.7 | 9 | 5 | 64.3 | 5 | 8 | 38.5 |
1
There was a higher loss of heterozygosity (LOH) frequency of D9S942 in the high-risk than in non-high-risk tumors (P < 0.05, χ2 = 4.47). There were no substantial differences in LOH frequencies among three groups of 4 markers.