Rate depression of the Hoffmann reflex at different time points after spinal cord injury in TNC–/– and TNC+/+ mice. Shown are mean values (±SEM) of H/M ratios at different stimulation frequencies before operation and 1, 3, 6, and 12 weeks after spinal cord injury. At 6 and 12 weeks after injury, the H/M ratios in TNC–/– mice are significantly lower than in TNC+/+ littermates at high frequencies (analysis of variance for repeated measurements with Tukey's post hoc test, *P < 0.05). Number of animals are indicated in parenthesis. TNC, tenascin-C.