Figure 1.

Characterization of the inflammatory response in the eyes of retinoblastoma patients injected with the Ad-RSVtk vector. (a) Pathological definitions of immunostaining grades for retinoblastoma eyes. Enucleated eyes from unilateral retinoblastoma patients and Ad-RSVtk-treated retinoblastoma subjects were stained with antibodies against different cell surface antigens. Based on staining, trained pathologists assigned grades of 0–4. Bar = 200 µm. (b) Median grade observed for different markers in retinoblastoma patients who received (n = 7) or did not receive (n = 6) the Ad-RSVtk vector followed by ganciclovir. Grading was determined for each characteristic area of the eye. AC, anterior chamber; APC, antigen-presenting cell; CB, ciliary body; Vit, vitreous.